Standard Test Method for Measuring the Size of Nanoparticles in Aqueous Media Using Dynamic Light Scattering

Importancia y uso:

5.1 Particle size is a key property of manufactured or engineered nanoparticles used in a wide range of applications. For purposes relevant to evaluations of safety, effectiveness, performance, quality, public health impact, or regulatory status of products, the correct measurement and uniform reporting of size and related parameters under use conditions, or during the manufacturing process, are critical to suppliers, analysts, regulators and other stakeholders.

5.2 This test method is intended principally for the analysis of nanoparticles in aqueous suspension with dimensions between about 1 nm and 100 nm, but may be applied to diffusive colloidal particles even if their dimensions fall outside the nanoscale range (up to roughly 1000 nm). For larger sizes, alternative techniques should be considered.

5.3 For more detailed guidance on DLS measurements, including operational aspects, refer to Appendix X2 of this test method.

Note 1: The user is also referred to Guide E2490, which provides broad guidance for the application of DLS to nanomaterials. Guide E2490 is not required for the implementation of this test method.

Subcomité:

E56.02

Referida por:

E3483-25, E3409-24, E3427-24, E3439-25

Volúmen:

14.02

Número ICS:

07.120 (Nanotechnologies)

Palabras clave:

dynamic light scattering; hydrodynamic size; light scattering; nanoparticle; particle size; particle size distribution; photon correlation spectroscopy; quasi-elastic light scattering; regulatory science; regulatory submission;