Standard Test Method for Determination of Bromadiolone, Brodifacoum, Diphacinone and Warfarin in Water by Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Importancia y uso:

5.1 This test method has been developed by U.S. EPA Region 5 Chicago Regional Laboratory (CRL).

5.2 Bromadiolone, brodifacoum, diphacinone and warfarin are rodenticides for controlling mice, rats, and other rodents that pose a threat to public health, critical habitats, native plants and animals, crops, food and water supplies. These rodenticides also present human and environmental safety concerns. Warfarin and diphacinone are first-generation anticoagulants, while bromadiolone and brodifacoum are second-generation. The anticoagulants interfere with blood clotting, and death can result from excessive bleeding. The second-generation anticoagulants are especially hazardous for several reasons. They are highly toxic and persist a long time in body tissues. The second-generation anticoagulants are designed to be toxic in a single feeding, but time-to-death occurs in several days. This allows rodents to feed multiple times before death, leading to carcasses containing residues that may be many times the lethal dose.4

5.3 This test method has been investigated for use with reagent, surface, and drinking water for the selected rodenticides.

Subcomité:

D19.06

Volúmen:

11.02

Número ICS:

13.060.50 (Examination of water for chemical substances)

Palabras clave:

liquid chromatography; mass spectrometry; rodenticides; water;