Standard Test Method for Measurement of Airborne Metal Oxide Nanoparticle Surface Area Concentration in Inhalation Exposure Chambers using Krypton Gas Adsorption

Importancia y uso:

5.1 A tiered strategy for characterization of nanoparticle properties is necessary to draw meaningful conclusions concerning dose-response relationships observed during inhalation toxicology experiments. This tiered strategy includes characterization of nanoparticles as produced (that is, measured as the bulk material sold by the supplier) and as administered (that is, measured at the point of delivery to a test subject) (Oberdorster et al. (6)).

5.2 Test Methods B922 and C1274 and ISO 9277 and ISO 18757 exist for determination of the as produced surface area of bulk metal and metal oxide powders. During the delivery of nanoparticles in inhalation exposure chambers, the material properties may undergo change and therefore have properties that differ from the material as produced. This test method describes the determination of the as administered surface area of airborne metal oxide nanoparticles in inhalation exposure chambers for inhalation toxicology studies.

Subcomité:

E56.02

Volúmen:

14.02

Número ICS:

07.120 (Nanotechnologies), 49.025.05 (Ferrous alloys in general)

Palabras clave:

BET surface area; gas sorption analysis; inhalation exposure; krypton; metal and metal oxide nanoparticles; multipoint surface area; outgassing; physical adsorption; surface area;