Standard Practice for Within-laboratory Quantitation Estimation (WQE)

Importancia y uso:

5.1 Appropriate application of this practice should result in a WQE achievable by the laboratory in applying the tested method/matrix/analyte combination to routine sample analysis. That is, a laboratory should be capable of measuring concentrations greater than WQE_Z %, with the associated RSD equal to Z % or less.

5.2 The WQE values may be used to compare the quantitation capability of different methods for analysis of the same analyte in the same matrix within the same laboratory.

5.3 The WQE procedure should be used to establish the within-laboratory quantitation capability for any application of a method in the laboratory where quantitation is important to data use. The intent of the WQE is not to impose reporting limits. The intent is to provide a reliable procedure for establishing the quantitative characteristics of the method (as implemented in the laboratory for the matrix and analyte) and thus to provide the laboratory with reliable information characterizing the uncertainty in any data produced. Then the laboratory can make informed decisions about censoring data and has the information necessary for providing reliable estimates of uncertainty with reported data.

Subcomité:

D19.02

Volúmen:

11.01

Número ICS:

17.020 (Metrology and measurement in general)

Palabras clave:

critical limits; matrix effects; precision; quantitation; quantitation limits;