Standard Test Method for Determination of the Mass Fraction of Particle-Bound Gold in Colloidal Gold Suspensions

Importancia y uso:

5.1 Au nano-objects in various shapes (that is, rods, particles) are increasingly used for a wide variety of applications. Medical applications of AuNPs, such as targeted drug delivery, tumor detection, and treatment are becoming more common (5). AuNPs have unique optical properties related to their size and their surface can be readily functionalized. Though Au is recognized to be inert and biocompatible in its bulk form, the behavior of Au nano-objects in biological systems and the environment must be tested to ensure their inertness and safety (6). It is important to know whether prepared and stored suspensions of AuNPs contain Au in its bound state (commonly Au (0) and particle adsorbed species) or ionized state (commonly, Au (I) or Au (III)) to attribute the biological response to the appropriate species. Krug, et al., concluded that the significance of toxicity studies is considerably reduced in those cases where the material properties of the nanomaterial suspensions were not characterized prior to and during the study (7). Furthermore, the analyte mass fraction of particle bound species is used with knowledge of particle size to compute particle number concentration.

Subcomité:

E56.02

Volúmen:

14.02

Número ICS:

71.040.40 (Chemical analysis)

Palabras clave:

Au; colloidal suspension; mass spectrometry; nanoparticles; optical emission spectrometry; particle-bound Au;