Standard Test Method for Estimating Acute Oral Toxicity in Rats

Importancia y uso:

5.1 This test method is of principal value in minimizing the number of animals required to estimate the acute oral toxicity (LD50). It also incorporates measures of variance (95 % CI) and a slope from which to make relative toxicity comparisons.

5.2 This test method is inappropriate for materials typically producing death two or more days after administration of the test compound unless the observation time between dosages is increased. This test method can be successfully applied, however, for materials producing only an occasional death two or more days after administration.

5.3 The LD50 is valuable as a measure of the relative acute toxicity of a material and can be used to make an estimate of potential hazard to humans when pesticides, other chemicals, or mixtures are ingested.

5.4 This test method allows for observation of signs of toxicity in addition to mortality. This information can be useful in planning additional toxicity testing.

Subcomité:

E50.47

Referida por:

E2552-23

Volúmen:

11.09

Número ICS:

65.100.99 (Other pesticides and agrochemicals)

Palabras clave:

chemicals; LD50; oral toxicity; pesticides; rats;