Standard Practice for Conducting Subacute Dietary Toxicity Tests with Avian Species

Importancia y uso:

5.1 This practice provides a means of measuring the susceptibility of an avian species to a test substance in its diet under controlled conditions. The LC₅₀ obtained in this test is a conditional measure of subacute toxicity because consumption is voluntary, and because the dietary route may introduce metabolic transformations of the test substance that might be absent in other exposure techniques.

5.2 Use of this practice contributes to the evaluation of the hazards of chemicals to birds because exposure is analogous to most field exposures, that is, through dietary intake.

5.3 The use of this practice allows for observation of signs of toxicity in addition to mortality.

5.4 The dose-response curve provides additional information about the response of birds to a test substance.

5.5 This practice can be used to study the effects of test substances in combination in order to simulate situations where birds may be exposed to more than one substance simultaneously (1).3

5.6 This practice provides one basis for deciding whether additional toxicity testing should be conducted with birds.

Subcomité:

E50.47

Referida por:

E2552-23

Volúmen:

11.09

Número ICS:

65.120 (Animal feeding stuffs)